推荐产品
生物源
mouse
品質等級
共軛
peroxidase conjugate
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
9E10, monoclonal
形狀
lyophilized powder
物種活性
human
包裝
vial of 100 μL
濃度
~2 mg/mL
技術
immunoblotting: 1:250-1:500 using lysate of HEK-293T cells over expressing c-Myc fusion protein
immunohistochemistry: suitable
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MYC(4609)
一般說明
c-Myc单克隆抗体（小鼠IgG1亚型）来源于小鼠骨髓瘤细胞和KLH偶联人p62c-myc蛋白合成多肽免疫的BALB/c小鼠脾细胞融合而产生的9E10杂交瘤细胞。c-Myc是位于人类8号染色体长臂上的原癌基因。编码蛋白含有N端转录激活结构域。人c-Myc原癌基因是在几种致白血病逆转录病毒中发现的禽类v-Myc基因的人细胞同源物。
特異性
调宁蛋白单克隆抗体特异性识别平滑肌调宁蛋白(Calponin)。
免疫原
人 p62c-myc 蛋白的合成肽。
應用
小鼠抗c-Myc-过氧化物酶单克隆抗体可用于免疫印迹和免疫组化技术。
生化／生理作用
c-Myc是一种参与细胞生长、增殖、分化和凋亡调节的转录因子。与DNA复制、RNA剪接或转录有关。该基因过表达与多种人类癌症的发生发展有关。
外觀
以冻干粉形式提供。用0.1 mL蒸馏水重悬(reconstitution)至∼ 2 mg/mL的最终抗体浓度，溶液为含有1% BSA、2.5% 海藻糖和0.05% MIT的0.01M 磷酸钠缓冲液
儲存和穩定性
冻干产品2–8 °C储存。重新配制(reconstitution)后，若要延长储存时间，请以等分试样储存于-20°C。应避免反复冻融循环。重新配制(reconstitution)后如需继续使用，可在2-8 °C下储存至多一月。稀释的工作溶液在12小时后应当被丢弃。
免責聲明
除非我们的产品目录另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
K Alitalo et al.
Nature, 306(5940), 274-277 (1983-11-17)
The myelocytomatosis viruses are a family of replication-defective avian retroviruses that cause a variety of tumours in chickens and transform both fibroblasts and macrophages in culture through the activity of their oncogene v-myc. A closely related gene (c-myc) is found
S Pelengaris et al.
Current opinion in genetics & development, 10(1), 100-105 (2000-02-19)
The protein products of many dominant oncogenes are capable of inducing both cell proliferation and apoptosis. Recent experiments employing transgenic mice that express an ectopically regulatable myc gene or protein have begun to elucidate the role of the balance between
Q Hu et al.
Science (New York, N.Y.), 268(5207), 100-102 (1995-04-07)
Phosphatidylinositol (Pl)-3 kinase is one of many enzymes stimulated by growth factors. A constitutively activated mutant, p110, that functions independently of growth factor stimulation was constructed to determine the specific responses regulated by Pl-3 kinase. The p110 protein exhibited high
Ann-Marie Baker et al.
Histopathology, 69(2), 222-229 (2016-01-31)
Recent attempts to study MYC distribution in human samples have been confounded by a lack of agreement in immunohistochemical staining between antibodies targeting the N-terminus and those targeting the C-terminus of the MYC protein. The aim of this study was
D Robertson et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 43(5), 471-480 (1995-05-01)
To determine the ultrastructural distribution of H-ras, the rho proteins rho-A, rho-B, rho-C, and the rac1 protein (members of the ras GTP-binding protein family), we used cDNA expression plasmids in which a short sequence coding for the epitope recognized by
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