所有图片(1)
About This Item
经验公式（希尔记法）:
C22H36O3
CAS号:
分子量:
348.52
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.77
推荐产品
形狀
powder
品質等級
儲存條件
protect from light
顏色
white to beige
溶解度
DMSO: ≥20 mg/mL
儲存溫度
−20°C
SMILES 字串
CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O
InChI
1S/C22H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h15,17-18,23H,2-14,16H2,1H3,(H,24,25)
InChI 密鑰
ADFWQBGTDJIESE-UHFFFAOYSA-N
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應用
漆树酸已：
- 用作组蛋白乙酰化酶(HAT)抑制剂，以研究其对大鼠皮层神经元的影响
- 用作体外乙酰化试验的阳性对照
- 用作乙酰化酶抑制剂，以研究其对转染人胚胎肾细胞的核糖核酸输出1 (Rae-1)蛋白乙酰化的影响
生化／生理作用
漆树酸是 HAT（组蛋白乙酰转移酶）抑制剂。
漆树酸是一种从腰果果壳中提取的天然生物活性化合物。它具有抗真菌、抗菌、抗白蚁和杀软体动物的活性。漆树酸作为一种治疗剂，可对抗肥胖、癌症、炎症疾病和氧化损伤。它作为各种酶的抑制剂，如脂氧合酶(LOX-1)、黄嘌呤氧化酶、核因子κ B (NFκB)激酶、酪氨酸酶和脲酶。
特點和優勢
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Basic and Clinical Pharmacology and Toxicology, doi: 10-doi: 10 (2011)
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European journal of medicinal chemistry, 47(1), 337-344 (2011-11-22)
Histone acetyltransferases are important enzymes that regulate various cellular functions, such as epigenetic control of DNA transcription. Development of HAT inhibitors with high selectivity and potency will provide powerful mechanistic tools for the elucidation of the biological functions of HATs
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