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About This Item
经验公式（希尔记法）:
C16H11N3O3
CAS号:
分子量:
293.28
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
yellow to brown
溶解度
DMSO: ≥10 mg/mL
儲存溫度
2-8°C
SMILES 字串
[O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
InChI
1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
InChI 密鑰
OLUKILHGKRVDCT-UHFFFAOYSA-N
基因資訊
rat ... Gsk3b(84027)
應用
Alsterpaullone 已用于稳定 β-catenin。
Alsterpaullone 抑制 GSK-3β、CDK5/p25 和 CDK1/cyclinB。Alsterpaullone 也已被作为抗躁狂药进行研究，用于双相情感障碍急性躁狂期的治疗。
生化／生理作用
Alsterpaullone（ALP）是一种细胞周期蛋白依赖性激酶（CDK）抑制剂。它被认为是第 3 组髓母细胞瘤的治疗药物。Alsterpaullone 调节细胞周期的进程。它可以通过干扰线粒体膜电位来激活 caspase-9，从而阻止细胞周期并刺激癌细胞凋亡。
GSK-3β 和 CDK5/p25; 的有效和选择性抑制剂；CDK1/cyclin B 的有效抑制剂（IC50 = 0.035 μM）。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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C Schultz et al.
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