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Merck

A4529

Sigma-Aldrich

Aprotinin

3-7 TIU/mg solid, lyophilized powder

别名:

BPTI, 抑肽酶, 牛胰胰蛋白酶抑制剂, 胰蛋白酶抑制剂(碱性)

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About This Item

经验公式(希尔记法):
C284H432N84O79S7
CAS号:
分子量:
6511.44
EC號碼:
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.54

product name

抑肽酶 来源于牛肺, lyophilized powder, 3-7 TIU/mg solid

生物源

bovine lung

形狀

lyophilized powder

比活性

3-7 TIU/mg solid

分子量

~6,500

溶解度

H2O: >10 mg/mL

UniProt登錄號

儲存溫度

2-8°C

InChI 密鑰

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

基因資訊

cow ... PTI(404172)

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應用

抑肽酶被大量用作胰蛋白酶抑制剂。

生化/生理作用

抑肽酶是一种竞争性丝氨酸蛋白酶抑制剂,可与酶的活性位点组成稳定的复合酶并同时对其进行封闭。 这种结合是可逆的,而且绝大多数抑肽酶-蛋白酶复合物可在极端的pH >10 or < 3水平时发生解离。 从结构上来说,抑肽酶是一种来自牛肺的单体球状蛋白,由58个氨基酸组成并排列在具有三个交联二硫键的单个多肽链中。

單位定義

一个胰蛋白酶抑制剂单位(TIU)可将两个胰蛋白酶单位的活性降低50%,而其中一个胰蛋白酶单位在pH 7.8和25℃下可每分钟水解1.0 μ摩尔的N-α-苯甲酰基-DL-精氨酸对硝基苯胺。另一种常用的单位是KIU,而1 TIU = 1,300 KIU。

準備報告

This product is an affinity purified lyophilized powder purified to remove trace impurities. It has an activity of 3-7 TIU/mg.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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实验方案

Objective: To standardize a procedure for the enzymatic assay of Aprotinin.

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