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Merck

A231

Sigma-Aldrich

花生四烯基三氟甲基酮

oil, ≥97% (NMR)

别名:

1,1,1-三氟甲基-6,9,12,15-heieicosatetraen-2-酮, AACOCF3, Arach-CF3

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About This Item

经验公式(希尔记法):
C21H31F3O
分子量:
356.47
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥97% (NMR)

形狀

oil

儲存條件

desiccated
protect from light
under inert gas

顏色

yellow

溶解度

DMSO: >5 mg/mL

儲存溫度

−20°C

SMILES 字串

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F

InChI

1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-

InChI 密鑰

PLWROONZUDKYKG-DOFZRALJSA-N

基因資訊

human ... PLA2G1B(5319)

應用

花生四烯酸三氟甲基酮(AACOCF3)已被用作阿那达胺降解抑制剂,以研究其在原代星形胶质细胞培养物中的作用。

生化/生理作用

花生四烯酸三氟甲基酮(AACOCF3)在抑制血小板产生的12-羟基二十碳四烯酸(12-HETE)和血栓烷B2中起作用。
体外抑制大麻素水解;抑制磷脂酶A2

特點和優勢

该化合物在受体分类和信号转导手册的磷脂酶A2 页面上有重点介绍。想要浏览手册的其他页面, 请单击此处

注意

吸湿性、光敏性、空气敏感性

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析证书(COA)

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B Cinque et al.
International journal of immunopathology and pharmacology, 21(3), 539-551 (2008-10-04)
Various molecular mechanisms have been suggested to be involved in dexamethasone induced thymocyte apoptosis. In this study we show that pharmacological inhibition of cytoplasmic PLA2 in mouse thymocytes for 18 h with arachidonyl trifluoromethyl ketone (AACOCF3) (10 microM) and palmitoyl
Wen Li et al.
Biochemistry, 47(52), 13997-14008 (2008-12-10)
TCDD (dioxin) induces a rapid inflammatory response from 3T3-L1 adipocytes as judged by prominent induction of the mRNA expression of prostaglandin-endperoxide synthase 2 (Cox-2) along with other inflammation markers within 1 h. This action of TCDD is clearly antagonized by
Gavin Pharaoh et al.
Scientific reports, 10(1), 13968-13968 (2020-08-20)
Defects in neuromuscular innervation contribute significantly to the age-related decline in muscle mass and function (sarcopenia). Our previous studies demonstrated that denervation induces muscle mitochondrial hydroperoxide production (H2O2 and lipid hydroperoxides (LOOHs)). Here we define the relative contribution of mitochondrial
Wenlong Huang et al.
Journal of neurotrauma, 26(8), 1429-1434 (2009-04-18)
In spinal cord injury (SCI), neuronal and oligodendroglial loss occurs as a result of the initial trauma and the secondary damage that is triggered by excitotoxicity, free radicals, and inflammation. There is evidence that SCI ellicits increased cytosolic phospholipase A(2)
Amanda Linkous et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(5), 1635-1644 (2009-02-26)
In vascular endothelial cells, low doses of ionizing radiation trigger the immediate activation of cytosolic phospholipase A2 (cPLA2). This event initiates prosurvival signaling that could be responsible for radioresistance of tumor vasculature. Thus, the development of radiosensitizers targeting these survival

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