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About This Item
经验公式（希尔记法）:
C22H32O2
CAS号:
分子量:
328.49
Beilstein:
1715505
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.25
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生物源
algae
品質等級
化驗
≥98%
形狀
liquid
官能基
carboxylic acid
脂質類型
omega FAs
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O
InChI
1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
InChI 密鑰
MBMBGCFOFBJSGT-KUBAVDMBSA-N
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一般說明
二十二碳六烯酸（DHA）大量存在于大脑中。
二十二碳六烯酸（DHA）是一种含22个碳和6个双键的ω-3多不饱和脂肪酸，其第一个双键位于甲基末端的第3位（22：6 n-3）。 它是脂质膜和髓鞘的组分。
應用
cis-4,7,10,13,16,19-二十二碳六烯酸已用于：
- 用作杜氏改良Eagle培养基（DMEM）的组分，用于培养细胞进行二十二碳六烯酸（DHA）处理
- 研究其在分子和细胞水平上对人诱导多能干细胞（iPSC）衍生神经元的影响
- MTT[3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四氮唑]试验，研究对3种人肝细胞癌（HCC）细胞系（HepG2、Hep3B、Huh7）的细胞毒性作用
生化／生理作用
二十二碳六烯酸（DHA）参与中枢神经系统的生长和生理活动。它可以调节成人神经发生和神经可塑性。DHA在胎儿大脑发育中起重要作用。它可能表现出抗氧化和抗炎的特性。DHA在细胞膜流动性的调节中起重要作用。它在几个大脑发育过程中起着至关重要的作用，包括神经递质释放、基因表达、髓鞘形成、神经炎症和神经元分化。DHA对几种癌症都有抗癌作用。
二十二碳六烯酸（DHA）还可用作前列腺素和类二十烷酸等信号传导分子的前体。
包裝
安瓿瓶装。
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
143.6 °F - closed cup
閃點（°C）
62 °C - closed cup
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
其他客户在看
G Kargas et al.
Journal of chromatography, 526(2), 331-340 (1990-04-06)
A rapid, simple and highly sensitive reversed-phase high-performance liquid chromatographic method is described for the separation and quantitation of fatty acids in human serum using a very reactive fluorescent labeling reagent, 9-anthryldiazomethane. Quantitative esterification proceeds at room temperature without heat
M Martínez
Neurology, 40(8), 1292-1298 (1990-08-01)
In confirmation of previous findings, patients with Zellweger's syndrome had extremely low levels of docosahexaenoic acid (22:6 omega 3) in the brain, liver, and kidneys. The other product of delta 4 desaturation, 22:5 omega 6, was also very significantly decreased
Ana M Torres-Guzman et al.
Arthritis research & therapy, 16(2), R64-R64 (2014-03-13)
Clinical and preclinical studies have shown that supplementation with ω-3 polyunsaturated fatty acids (ω-3 PUFAs) reduce joint destruction and inflammation present in rheumatoid arthritis (RA). However, the effects of individual ω-3 PUFAs on chronic arthritic pain have not been evaluated
Eduardo Luiz Moreira et al.
Toxicological sciences : an official journal of the Society of Toxicology, 130(2), 373-382 (2012-08-21)
Methylmercury (MeHg) is an environmental pollutant that biomagnifies throughout the aquatic food chain, thus representing a toxicological concern for humans subsiding on fish for their dietary intake. Although the developing brain is considered the critical target organ of MeHg toxicity
Richard J Woodman et al.
Atherosclerosis, 166(1), 85-93 (2002-12-17)
Type 2 diabetes and hypertension are both associated with an increased risk of atherothrombosis. We assessed whether purified eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish oil have differential effects on platelet, fibrinolytic and vascular function in patients with
商品
The potential for the prevention and treatment of cardiovascular disease through increased dietary intake of omega-3 (w-3) fish oils is not a recent scientific discovery.
Lipid Induced Insulin Resistance
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