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Merck

A1625

Sigma-Aldrich

乙酰乙酰辅酶 A 钠盐 水合物

cofactor for acyl transfer

别名:

乙酰乙酰-CoANa3

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About This Item

经验公式(希尔记法):
C25H40N7O18P3S · xNa+ · yH2O
CAS号:
分子量:
851.61 (anhydrous free acid basis)
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic (Organic)

品質等級

化驗

≥90%

形狀

powder

溶解度

H2O: soluble~-50 g/L

儲存溫度

−20°C

SMILES 字串

[Na+].[Na+].[Na+].CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP([O-])(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n2cnc3c(N)ncnc23

InChI

1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t14-,18-,19-,20+,24-/m1/s1

InChI 密鑰

OJFDKHTZOUZBOS-CITAKDKDSA-N

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應用

乙酰乙酰-CoA硫解酶EC 2.3.1.9的底物;在无活菌素的生物合成中发挥作用。
乙酰乙酰辅酶A(乙酰乙酰-CoA)可用作许多酶的底物,包括:在反向缩合反应中产生乙酰辅酶A的乙酰乙酰-CoA硫解酶(EC2.3.1),以及在甲羟戊酸途径中产生3-羟基-3-甲基戊二酰(HMG)辅酶A并导致萜类化合物生物合成的(3-羟基-3-甲基戊二酰辅酶A(CoA)合成酶(HMGCS))。 乙酰乙酰-CoA也是微生物中聚-β-羟基丁酸酯聚合物的前体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Tamay Seker et al.
Applied microbiology and biotechnology, 67(1), 119-124 (2004-09-28)
The mevalonate pathway plays an important role in providing the cell with a number of essential precursors for the synthesis of biomass constituents. With respect to their chemical structure, the metabolites of this pathway can be divided into two groups:
Petri Kursula et al.
Biochemistry, 41(52), 15543-15556 (2002-12-27)
Biosynthetic thiolase catalyzes the formation of acetoacetyl-CoA from two molecules of acetyl-CoA. This is a key step in the synthesis of many biological compounds, including steroid hormones and ketone bodies. The thiolase reaction involves two chemically distinct steps; during acyl
E B Taylor et al.
American journal of physiology. Endocrinology and metabolism, 288(6), E1055-E1061 (2005-01-13)
Activation of the AMP-activated protein kinase (AMPK) results in acute changes in cellular metabolism and transcriptional events that make the cell more robust when encountering an energy challenge. AMPK is thought to be inhibited by glycogen, the major storage form
Ryan Sillers et al.
Biotechnology and bioengineering, 102(1), 38-49 (2008-08-30)
Metabolic engineering (ME) of Clostridium acetobutylicum has led to increased solvent (butanol, acetone, and ethanol) production and solvent tolerance, thus demonstrating that further efforts have the potential to create strains of industrial importance. With recently developed ME tools, it is
Michael J Theisen et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(47), 16442-16447 (2004-10-23)
The formation of carbon-carbon bonds via an acyl-enzyme intermediate plays a central role in fatty acid, polyketide, and isoprenoid biosynthesis. Uniquely among condensing enzymes, 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase (HMGS) catalyzes the formation of a carbon-carbon bond by activating the methyl group

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