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A0673

Sigma-Aldrich

人肾上腺皮质激素片段 18-39

≥97% (HPLC)

别名:

CLIP

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About This Item

经验公式（希尔记法）:
C112H165N27O36
CAS号:
53917-42-3
分子量:
2465.67
MDL號碼:
MFCD00076159
分類程式碼代碼:
51111800
PubChem物質ID:
24890445
NACRES:
NA.32

無菌

non-sterile

品質等級

200

化驗

≥97% (HPLC)

形狀

powder

UniProt登錄號

P01189

儲存溫度

−20°C

SMILES 字串

CC(C)CC(NC(=O)C1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C3CCCN3C(=O)C(Cc4ccc(O)cc4)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(NC(=O)C5CCCN5C(=O)C(N)CCCNC(N)=N)C(C)C)C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(Cc6ccccc6)C(O)=O

InChI

1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118)

InChI 密鑰

ZYDMZKPAPSZILB-UHFFFAOYSA-N

基因資訊

human ... POMC(5443)

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相关类别

Amino Acid Sequence

Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

一般說明

促肾上腺皮质激素 (ACTH) 由其前体阿黑皮素原 (POMC) 合成。在下丘脑促肾上腺皮质激素释放激素 (CRH) 的作用下，由垂体前叶释放。ACTH 的编码基因定位于人染色体 2p23.3。

應用

促肾上腺皮质激素片段 18-39 人已用于基质辅助激光解吸/离子化 (MALDI)-TOF-MS 和 MALDI-MS。

生化／生理作用

促肾上腺皮质激素(ACTH)通过cAMP依赖于肾上腺中G蛋白偶联受体的刺激来刺激糖皮质激素和雄激素的合成和释放。ACTH的过量生产会导致皮肤色素沉着。
对大鼠异相睡眠的促进作用：刺激胰岛素释放。

其他說明

通过 H 2 O 中的 0.1% TFA冻干

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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