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一般說明
研究领域：神经科学
醇脱氢酶的同源二聚体结构在C端具有辅酶结合结构域，在N末端具有催化结构域。活动部位位于域间裂隙。NAD+在活性位点的结合会引起构象变化，从而形成醇底物的结合位点。
醇脱氢酶的同源二聚体结构在C端具有辅酶结合结构域，在N末端具有催化结构域。活动部位位于域间裂隙。NAD+在活性位点的结合会引起构象变化，从而形成醇底物的结合位点。
應用
醇脱氢酶（ADH）被用于逆转精神分裂症断裂基因1（DISC1-FL）和DB7细胞裂解物中缺乏的3-[4,5-二甲基噻唑-2-基]-2,5二苯基四唑溴化物（MTT）测定的减少。
生化／生理作用
醇脱氢酶催化醇氧化转化为醛。醇脱氢酶（ADH）催化的乙醇代谢引发活性氧（ROS）和一氧化氮（NO）的产生，导致线粒体和细胞蛋白氧化损伤，并进一步与神经炎症和神经系统疾病的发生有关。
單位定義
一个单位对应于在pH 7.0和30℃（NADPH作为辅助因子）下，每分钟减少1 μmol丙酮所需的酶量
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves
Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 A resolution.
H Eklund et al.
Journal of molecular biology, 146(4), 561-587 (1981-03-15)
F Colonna-Cesari et al.
The Journal of biological chemistry, 261(32), 15273-15280 (1986-11-15)
A study of the hinge bending mode in the enzyme liver alcohol dehydrogenase is made by use of empirical energy functions. The enzyme is a dimer, with each monomer composed of a coenzyme binding domain and a catalytic domain with
H Eklund et al.
Biochemistry, 23(25), 5982-5996 (1984-12-04)
The binding of NAD to liver alcohol dehydrogenase has been studied in four different ternary complexes by using crystallographic methods. These complexes crystallize isomorphously in a triclinic crystal form which contains the whole dimer of the enzyme in the asymmetric
Tomáš Pluskal et al.
Nature plants, 5(8), 867-878 (2019-07-25)
Kava (Piper methysticum) is an ethnomedicinal shrub native to the Polynesian islands with well-established anxiolytic and analgesic properties. Its main psychoactive principles, kavalactones, form a unique class of polyketides that interact with the human central nervous system through mechanisms distinct
Albert Rosell et al.
Journal of molecular biology, 330(1), 75-85 (2003-06-24)
The amphibian enzyme ADH8, previously named class IV-like, is the only known vertebrate alcohol dehydrogenase (ADH) with specificity towards NADP(H). The three-dimensional structures of ADH8 and of the binary complex ADH8-NADP(+) have been now determined and refined to resolutions of
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