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17944

1α,25-二羟维生素 D₂

Name: 1α,25-二羟维生素 D<SUB>2</SUB>
Brand: SIGMA

≥97.0% (sum of vitamin and previtamin, HPLC)

别名:

1α,25-二羟骨化醇

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About This Item

经验公式（希尔记法）:

C₂₈H₄₄O₃

CAS号:

60133-18-8

分子量:

428.65

Beilstein:

5635017

MDL號碼:

MFCD00869499

分類程式碼代碼:

12352205

PubChem物質ID:

57647692

NACRES:

NA.79

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1α,25-二羟基维生素D₃ (6,19,19-d₃) 溶液

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1α,25-二羟基维生素D₃

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1α,25-二羟基维生素D2标准液溶液

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S3674

琥珀酸

Sigma-Aldrich

705993

3-表-25-羟基维生素 D₃

Sigma-Aldrich

H4001

氢化可的松

Sigma-Aldrich

D2650

二甲基亚砜

生物源

synthetic

品質等級

200

化驗

≥97.0% (sum of vitamin and previtamin, HPLC)

形狀

crystals

顏色

white to light yellow

儲存溫度

−70°C

SMILES 字串

C[C@H](\C=C\[C@H](C)C(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C

InChI

1S/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25+,26+,28-/m1/s1

InChI 密鑰

ZGLHBRQAEXKACO-XJRQOBMKSA-N

生化／生理作用

麦角钙化醇（维生素 D2）在体内通过羟基化活化为 25-羟基麦角钙化醇和 1α，25-二羟基骨化醇。活化的维生素 D2 分子可用于广泛的研究，以评估其对免疫功能和钙稳态等功能的影响。

包裝

无底玻璃瓶。内含物装在插入的融合锥内。

42579

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象形圖

GHS06,GHS08

訊號詞

Danger

危險聲明

H301 + H311,H330,H372

防範說明

P260 - P264 - P280 - P302 + P352 + P312 - P304 + P340 + P310 - P314

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jun N-terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25-dihydroxyvitamin D3.

Qing Wang et al.

Journal of cellular biochemistry, 89(6), 1087-1101 (2003-08-05)

Recent studies revealed that the MEK/ERK module of the mitogen-activated protein kinase (MAPK) signaling cascades is up-regulated in the early stages of 1alpha,25-dihydroxyvitamin D(3) (1,25D(3))-induced monocytic differentiation of human leukemia cells HL60. In the present study, we investigated whether another

Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model.

Joanna Wietrzyk et al.

Cancer chemotherapy and pharmacology, 62(5), 787-797 (2008-01-12)

Active and less toxic vitamin D analogs could be useful for clinical applications. In the present study, we evaluated the toxicity and antitumor effect of two new synthetic analogs of vitamin D, namely PRI-1906 [(24E)-24a-Homo-(1S)-1,25-dihydroxyergocalciferol] and its side-chain unsaturated homo

Synthesis and antiproliferative activity of side-chain unsaturated and homologated analogs of 1,25-dihydroxyvitamin D(2). (24E)-(1S)-24-Dehydro-24a-homo-1,25-dihydroxyergocalciferol and congeners.

Michał Chodyński et al.

Steroids, 67(9), 789-798 (2002-07-19)

A series of analogs of 1,25-dihydroxyergocalciferol (1-4) was synthesized and screened for their antiproliferative activity in vitro. The structure of new analogs was designed based on biological activity of the previously obtained side-chain modified analogs of vitamin D(2) and D(3).

Rickets caused by excessive renal phosphate loss and apparent abnormal vitamin D metabolism in a cat.

R A Henik et al.

Journal of the American Veterinary Medical Association, 215(11), 1644-1649 (2003-10-22)

Rickets was diagnosed in a 1-year-old cat with a history of weakness, osteopenia, and recurrent fractures. Processes causing rickets include vitamin D deficiency caused by inadequate, nutrition, lack of exposure to sunlight, defective metabolism of parent vitamin D to active

Evaluation of bone markers in hypophosphatemic rickets/osteomalacia.

Yuki Nagata et al.

Endocrine, 40(2), 315-317 (2011-08-09)

N-terminal propeptide of type I procollagen (PINP) is a marker of newly formed type I collagen. However, its role in hypophosphatemic rickets/osteomalacia has not yet been established. Metabolic bone markers were examined in patients with oncogenic osteomalacia (OOM) and X-linked

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Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniquely initiated in the skin of vertebrates. During sun exposure, ultraviolet B photons are absorbed by 7-dehydrocholesterol, which is found within the plasma membranes of epidermal and dermal skin layers. This reaction yields an unstable derivative of 7-dehydrocholesterol, named precholecalcitrol, which rapidly rearranges to vitamin D3. Vitamin D binding protein (DBP) is a carrier protein responsible for drawing vitamin D3 from the plasma membrane into the dermal capillaries within the extracellular space.

LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5

≥97.0% (HPLC)

LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5

This application shows an Ascentis Express F5 provided rapid resolution of the isobaric vitamin D metabolites. MS detection provides the necessary secondary resolution.

主要文件

1α,25-二羟维生素 D2

≥97.0% (sum of vitamin and previtamin, HPLC)

About This Item

推荐产品

属性

生物源

品質等級

化驗

形狀

顏色

儲存溫度

SMILES 字串

InChI

InChI 密鑰

相关类别

说明

生化／生理作用

包裝

相关产品

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42579

安全信息

象形圖

訊號詞

危險聲明

防範說明

危險分類

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

個人防護裝備

文件

分析证书(COA)

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1α,25-二羟维生素 D₂