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Merck
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主要文件

113R-2

Sigma-Aldrich

CD13 (EP117) Rabbit Monoclonal Primary Antibody

别名:

Aminopeptidase-N

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About This Item

分類程式碼代碼:
12352203

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP117, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (113R-24)
vial of 0.1 mL concentrate Research Use Only (113R-24-RUO)
vial of 0.5 mL concentrate (113R-25)
vial of 1.0 mL concentrate (113R-26)
vial of 1.0 mL concentrate Research Use Only (113R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (113R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (113R-27)
vial of 7.0 mL pre-dilute ready-to-use (113R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (113R-28-RUO)

製造商/商標名

Cell Marque®

濃度

0.1-5 μg/mL (predilute)
2.5-125 μg/mL (concentrate)

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同型

IgG

控制

liver

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

cytoplasmic, membranous

基因資訊

human ... ANPEP(290)

一般說明

CD13 (aminopeptidase-N) is a transmembrane protease present in many tissues and cell types (e.g., endothelial and epithelial cells, fibroblasts, and leukocytes). CD13 is expressed in various solid and hematological malignancies in humans and is useful in identifying acute myeloid leukemia when used in a panel including antibodies against CD13(+), CD34(+), CD117(+), CD16(-), and CD33(+). This protein is also expressed in myeloid sarcoma and anti-CD13 is useful in its identification using a panel.

In addition, it has been reported that CD13 is expressed in both normal and neoplastic liver tissue, where it exhibits a canalicular distribution pattern similar to that seen for polyclonal CEA and CD10. Thus, anti-CD13 can be useful as an additional marker in differentiating between HCC and non-hepatocellular neoplasms.

品質

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

聯結

CD13 Positive Control Slides, Product No. 113S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
Piedfer M, et al.
Faseb Journal, 25, 2831-2842 (2011)
Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma.
Rocken C, et al.
Journal of Clinical Pathology, 58, 1069-1075 (2005)
Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.
Bauvois B, et al.
Medicinal Research Reviews, 26, 88-130 (2006)
Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients.
Pileri SA, et al.
Leukemia, 21, 340-350 (2007)
Acute promyelocytic leukemia: four distinct patterns by flow cytometry immunophenotyping.
Gorczyca, W.
Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists, 1, 8-17 (2012)

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