SMB00932

2-Deoxy-D-glucose 6-phosphate sodium salt

≥98% (HPLC)

• 别名: 2-Deoxy-D-glucose 6-phosphate sodium salt
• 经验公式（希尔记法）: C₆H₁₃O₈P · xNa⁺
• CAS号: 33068-19-8
• 分子量: 244.14 (free acid basis)
• MDL號碼: MFCD00057477
• 分類程式碼代碼: 12352201
• NACRES: NA.25

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white
• 溶解度: water: 50 mg/mL, clear, colorless
• 儲存溫度: −20°C
• SMILES 字串: [Na].OC(COP(O)(O)=O)C(O)C(O)CC=O
• InChI: 1S/C6H13O8P.Na.H/c7-2-1-4(8)6(10)5(9)3-14-15(11,12)13;;/h2,4-6,8-10H,1,3H2,(H2,11,12,13);;
• InChI 密鑰: NBDKYLFTCAOTAK-UHFFFAOYSA-N

说明

一般說明

2-Deoxy-D-glucose 6-phosphate sodium salt serves as a crucial intermediate in glycogen degradation. Its production in mammalian cells occurs through the action of hexokinase on 2-Deoxy-D-glucose (2-DG).

2-Deoxy-d-glucose (2DG) is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis). In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate (2DG6P) intracellularly. 2DG & 2DG6P serve as good markers for tissue glucose uptake and hexokinase activity. For example, many cancers have elevated glucose uptake and hexokinase levels. 2DG6P undergoes only the first enzymatic reaction in the pentose phosphate pathway to generate 2-DG-6-phosphogluconolactone, which cannot be further metabolized.

應用

2-Deoxy-D-glucose 6-phosphate sodium salt is a versatile compound that finds application in metabolomics and biochemical research.

特點和優勢

• High-purity compound suitable for a wide variety of research applications

其他說明

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安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable