PHR1696

泛昔洛韦

Pharmaceutical Secondary Standard; Certified Reference Material

• 别名: 泛昔洛韦, 2-[2-(2-氨基-9H-嘌呤-9-基)乙基]-1,3-丙二醇二乙酸酯, BRL 42810
• 经验公式（希尔记法）: C₁₄H₁₉N₅O₄
• CAS号: 104227-87-4
• 分子量: 321.33
• MDL號碼: MFCD00866964
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329823560
• NACRES: NA.24

属性

• 等級: certified reference material; pharmaceutical secondary standard
• 品質等級: 300
• agency: traceable to USP 1269152
• API 家族: famciclovir
• CofA: current certificate can be downloaded
• 包裝: pkg of 1 g
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• 應用: pharmaceutical (small molecule)
• 形式: neat
• 儲存溫度: 2-8°C
• SMILES 字串: CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O
• InChI: 1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
• InChI 密鑰: GGXKWVWZWMLJEH-UHFFFAOYSA-N

说明

一般說明

Famciclovir is an antiviral drug, which is predominantly used in the treatment of herpes virus infection. It is an inactive prodrug, which on administration, undergoes rapid biotransformation to penciclovir.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

應用

Famciclovir may be used as a reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化／生理作用

泛昔洛韦是一种抗逆转录病毒鸟苷类似物，用于治疗疱疹病毒感染和乙肝。泛昔洛韦可迅速转化为喷昔洛韦。病毒胸苷激酶将喷昔洛韦磷酸化为单磷酸形式，然后细胞激酶又将其转换为三磷酸喷昔洛韦。喷昔洛韦三磷酸可竞争性抑制病毒 DNA 聚合酶，从而抑制病毒复制。长时间服用会形成耐药性；这通常表现为筛选出了一批 DNA 聚合酶基因逆转录酶结构域突变的预先存在的耐药性菌株。

分析報告

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAC3254 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

推薦產品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable