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product name
CH27 Mouse B Cell Lymphoma Cell Line, CH27 mouse B cell lymphoma celll line is a useful model for the study of B-cell biology and tumor immunology.
生物源
mouse
品質等級
運輸包裝
ambient
一般說明
CH27 Mouse B Cell Lymphoma Cell Line is one of the CH series of mouse B-cell lymphomas that arise from the spleen cells of B10.H-2a-H-4b p/Wts (2a4b) mice, either spontaneously or after transplantation of the spleen cells to syngeneic or F1 hybrid recipients .
CH27 cells express surface IgM and Ia antigens along with Ly-1 (CD5) and Ig which bind sheep (SRBC) and chicken erythrocytes and bromelain-treated mouse erythrocytes . The hapten recognized by SRBC-binding CH lymphomas is a phospholipid, either phosphatidylchone or sphingomyelin . Phospholipids are a common component of cell membranes and thus cells expressing immunoglobulin with specificity for SRBC can also be found in the spleens of normal mice . This suggests that CH lymphomas represent neoplastic analogues of Ly-1+ normal B-cells .
CH27 cells express surface IgM and Ia antigens along with Ly-1 (CD5) and Ig which bind sheep (SRBC) and chicken erythrocytes and bromelain-treated mouse erythrocytes . The hapten recognized by SRBC-binding CH lymphomas is a phospholipid, either phosphatidylchone or sphingomyelin . Phospholipids are a common component of cell membranes and thus cells expressing immunoglobulin with specificity for SRBC can also be found in the spleens of normal mice . This suggests that CH lymphomas represent neoplastic analogues of Ly-1+ normal B-cells .
細胞系描述
Cancer Cells
應用
Research Category
Cancer
Immune Response
Inflammation & Immunology
Cancer
Immune Response
Inflammation & Immunology
This product is intended for sale and sold solely for internal non-commercial research use per the terms of the “Restricted Use Agreement” as detailed in the product documentation. For information regarding any other uses, please contact licensing@emdmillipore.com.
品質
• Each vial contains ≥ 1X106 viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination
儲存和穩定性
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
does not flash
閃點（°C）
does not flash
Transplantable B-cell lymphomas in B10. H-2aH-4bp/Wts mice.
L L Lanier et al.
Immunogenetics, 16(4), 367-371 (1982-01-01)
C A Pennell et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(11), 3799-3803 (1985-06-01)
A series of 27 B-cell lymphomas (designated the CH series), induced in B10.H-2aH-4b p/Wts mice by intense adoptive immunization with sheep erythrocytes, was found to represent a subset of the total B-cell repertoire. This subset was characterized by expression of
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