MAB10754
Anti-Caspase-8 (active form p18 subunit) Antibody, clone 2B12.1
clone 2B12.1, from mouse
别名:
caspase 8, apoptosis-related cysteine peptidase, caspase-8, caspase 8, apoptosis-related cysteine protease, MACH-beta-1/2/3/4 protein, Apoptotic protease Mch-5, Apoptotic cysteine protease, MACH-alpha-1/2/3 protein, FADD-homologous ICE/ced-3-like proteas
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所有图片(2)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
2B12.1, monoclonal
物種活性
human
技術
immunocytochemistry: suitable
western blot: suitable
同型
IgMκ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... CASP8(841)
一般說明
Caspase-8 (MACH/FLICE/Mch5) is a member of a family of cysteine-requiring aspartate proteases that participate in the intracellular signaling cascade leading to apoptosis, or programmed cell death. Caspase-8 is recruited to death-inducing signaling complex (DISC), CD95 (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) and is subsequently activated by proteolytic cleavage into two residues, p10 and p18. Active caspase-8 or the p18 subunit, is the first in the caspase signaling cascade, and it signals downstream caspases to eventually induce apoptosis.
特異性
This antibody recognizes the active form (p18 subunit) of Caspase-8.
免疫原
KLH-conjugated linear peptide corresponding to the active form of human Caspase-8.
應用
Detect Caspase-8 (active form p18 subunit) using this Anti-Caspase-8 (active form p18 subunit) Antibody, clone 2B12.1 validated for use in WB & IC.
Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected active Caspase-8 (p18 subunit) in etoposide-treated HeLa cells.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Caspases
Apoptosis - Additional
Caspases
Apoptosis - Additional
品質
Evaluated by Western Blot in camptothecin-treated and untreated Jurkat lysates.
Western Blot Analysis: 2 µg/mL of this antibody detected the active form of Caspase-8 (p18 subunit) in 10 µg of camptothecin-treated Jurkat lysates. Untreated jurkat lysate exhibited no detection of active Caspase-8.
Western Blot Analysis: 2 µg/mL of this antibody detected the active form of Caspase-8 (p18 subunit) in 10 µg of camptothecin-treated Jurkat lysates. Untreated jurkat lysate exhibited no detection of active Caspase-8.
標靶描述
~18 kDa observed
聯結
Replaces: 04-573; 04-574
外觀
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
Camptothecin-treated and untreated Jurkat lysates
Camptothecin-treated and untreated Jurkat lysates
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Paolo Petazzi et al.
Neurobiology of disease, 67, 49-56 (2014-03-25)
Epigenetic mechanisms are fundamental for shaping the activity of the central nervous system (CNS). Methyl-CpG binding protein 2 (MECP2) acts as a bridge between methylated DNA and transcriptional effectors responsible for differentiation programs in neurons. The importance of MECP2 dosage
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