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Merck
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Key Documents

14-418

Sigma-Aldrich

p300，HAT域

Recombinant GST-fusion protein corresponding to amino acids 1066-1707 of human p300.

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About This Item

分類程式碼代碼:
12352202
eCl@ss:
32160405
NACRES:
NA.41

生物源

human

品質等級

100

重組細胞

expressed in E. coli

分子量

Mw 100 kDa

製造商／商標名

Upstate®

技術

activity assay: suitable (histone acetyltransferase (HAT))

NCBI登錄號

NM_001429.2

UniProt登錄號

Q09472

運輸包裝

dry ice

基因資訊

human ... EP300(2033)

一般說明

产品来源：在大肠埃希菌中表达。

應用

与人p300氨基酸1066-1707相对应的重组GST融合蛋白。

品質

通过HAT分析进行常规评估。

單位定義

比活度：1单位定义为1 nmol[3H]-乙酸盐/分钟转移至酸提取的组蛋白。

儲存和穩定性

自收货之日起，在-20°C下最多保存6个月。

其他說明

关于比活相关数据，请参阅该酶单独批次的检验报告。

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

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A Giordano et al.
Journal of cellular physiology, 181(2), 218-230 (1999-09-25)
p300 and CBP are highly related nuclear proteins, which have been implicated in transcriptional responses to disparate extracellular and intracellular signals. There are at least two very good reasons for which p300 and CBP have attracted the attention of the
The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.
Weibin Wang,Kewu Pan,Yifan Chen,Chunyin Huang,Xiaowei Zhang
Nucleic Acids Research null
Dennis Shin-Shian Hsu et al.
Cancer cell, 26(4), 534-548 (2014-10-15)
Snail is primarily known as a transcriptional repressor that induces epithelial-mesenchymal transition by suppressing adherent proteins. Emerging evidence suggests that Snail can act as an activator; however, the mechanism and biological significance are unclear. Here, we found that CREB-binding protein
R L Schiltz et al.
The Journal of biological chemistry, 274(3), 1189-1192 (1999-01-09)
A number of transcriptional coactivators possess intrinsic histone acetylase activity, providing a direct link between hyperacetylated chromatin and transcriptional activation. We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes. p300 specifically acetylates
Junhui Xue et al.
Cancer letters, 471, 12-26 (2019-12-08)
Alpha-fetoprotein (AFP) is a well-established biomarker for hepatocellular carcinoma (HCC). Here, we investigated the acetylation state of AFP in vivo. AFP acetylation was regulated by the acetyltransferase CBP and the deacetylase SIRT1. Acetylation of AFP at lysines 194, 211, and

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