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一般說明
Beta Amyloid (1-42), ultra pure, HCl
MOL. WT.: 4514.3 Da by Mass Spec Analysis (theoretical 4514.10)
SEQUENCE: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
PEPTIDE CONTENT: 1 mg per vial; salt content is <10%
COUNTER ION: HCl
MOL. WT.: 4514.3 Da by Mass Spec Analysis (theoretical 4514.10)
SEQUENCE: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
PEPTIDE CONTENT: 1 mg per vial; salt content is <10%
COUNTER ION: HCl
應用
Different researchers claim enhanced activity due to different salts.
The TFA salt is what has been the industry standard.
The HFIP makes the beta-amyloid homogenously monomeric.
The NaOH apparently make it monomeric too and is also water soluble, which the TFA salt and HFIP are not.
The HCl salt is supposed to be more biological, as TFA is not found in the body.
By offering the different salts, it lets the researchers duplicate the different assays that have been developed by other researchers (see below).
TFA: Shu-chuan Jao, S-C, et. al. 1997, Amyloid; Int J Exp. Clinical Invest. 4, 231
HFIP: Stine, W.B. et. al. 2003, J. Biol. Chem, 278, 11612
NaOH: Fezoui, Y., et. al. 2000, Amyloid, 7, 166
HCL: Kanek, I and Tutumi, S., 1997, J. Neurochem, 68, 438
The TFA salt is what has been the industry standard.
The HFIP makes the beta-amyloid homogenously monomeric.
The NaOH apparently make it monomeric too and is also water soluble, which the TFA salt and HFIP are not.
The HCl salt is supposed to be more biological, as TFA is not found in the body.
By offering the different salts, it lets the researchers duplicate the different assays that have been developed by other researchers (see below).
TFA: Shu-chuan Jao, S-C, et. al. 1997, Amyloid; Int J Exp. Clinical Invest. 4, 231
HFIP: Stine, W.B. et. al. 2003, J. Biol. Chem, 278, 11612
NaOH: Fezoui, Y., et. al. 2000, Amyloid, 7, 166
HCL: Kanek, I and Tutumi, S., 1997, J. Neurochem, 68, 438
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
外觀
White lyophilized powder. Resuspend in any one of the following solvents: 0.1% TFA, 5 mM HCl, 2 mM NaOH, 0.2% NH4OH at a concentration of 1 mg/mL. Sonicate for 30 seconds to 1 minute after it has gone into solution. To bring into your solution: After resuspension, add 5x or 10x buffer stock (PBS, TBS) and water to bring to 1x buffer.
儲存和穩定性
Maintain lyophilized material at -20ºC for up to 12 months after date of receipt. After reconstitution maintain at -20ºC to -70ºC for up to 2 weeks in undiluted aliquots. Avoid freeze/thaw cycles to avoid aggregation.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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