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Amino Acid Sequence
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
一般說明
淀粉样蛋白β蛋白由淀粉样蛋白-β 前体蛋白（APP）产生。它由两个C末端变体组成，例如长尾的Aβ 1-42及短尾的Aβ 1-40。APP位于人染色体21q21.3。
應用
淀粉样蛋白β蛋白片段1-42已用于：
- Aβ 1-42低聚体的制备
- western blot分析
- 免疫磁性降低（IMR）血浆Aβ42检测的干扰试验
- 研究白藜芦醇对Aβ 1-42诱导的空间学习、记忆和突触可塑性损害的影响
- 研究Aβ在上皮细胞培养中的作用
生化／生理作用
在阿尔茨海默症和唐氏综合症患者的大脑中发现了淀粉样蛋白β-蛋白的主要片段。
淀粉样蛋白β蛋白片段1-42 (Aβ 1-42) 具有抗氧化及神经保护性质。淀粉样蛋白β蛋白的积累与阿尔兹海默症（AD）和唐氏综合症相关。Aβ 1-42可调节胆固醇的转运并可作为一种转录因子。它可能还具有抗炎及抗微生物的作用。
相關產品
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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