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Key Documents

AB3000

Sigma-Aldrich

抗IP3受体II型抗体

Chemicon®, from rabbit

别名:

Inositol 1,4,5-Trisphosphate Receptor

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

mouse, hamster, human, monkey, rat

製造商/商標名

Chemicon®

技術

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... ITPR2(3709)

特異性

兔抗II型肌醇1,4,5-三磷酸受体(IP3R)针对对应于大鼠II型受体羧基末端的合成肽。 该抗体可与来自大鼠、小鼠、人、仓鼠和猴的II型IP3R反应。

免疫原

一种对应于大鼠II型受体羧基末端的合成肽

應用

抗IP3受体II型抗体检测IP3受体II型的水平 &经发布 & 经验证可用于IC、IF、IH、IP & WB。
研究子类别
GPCR, cAMP/cGMP & 钙信号传导
研究类别
信号传导
蛋白质印迹:1:50 - 1:100(检测260 kDa条带)

免疫荧光: 1:10 - 1:20

免疫沉淀

免疫细胞化学:已知对AR4-2J,HL-60,COS-1,HEK-293和RBL-2H3细胞系具有阳性反应性。

免疫组化:多聚甲醛或甲醇固定剂有效。

最佳工作稀释度必须由最终用户进行确定。

外觀

亲和纯化与固定化免疫原肽。 PBS缓冲液中的液体,含有0.05%BSA,10%甘油,0.005%叠氮化钠。 注意:叠氮化钠是有害的。 可根据要求提供MSDS。

儲存和穩定性

若是保持冷冻在 -20°C 下,未稀释等分试样可保存长达 12 个月。

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2


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访问文档库

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.
Chen, R; Valencia, I; Zhong, F; McColl, KS; Roderick, HL; Bootman, MD; Berridge et al.
The Journal of cell biology null
Mark Chalmers et al.
The Biochemical journal, 394(Pt 1), 57-66 (2005-11-09)
The size and number of IP3R (inositol 1,4,5-trisphosphate receptor) clusters located on the surface of the ER (endoplasmic reticulum) is hypothesized to regulate the propagation of Ca2+ waves in cells, but the mechanisms by which the receptors cluster are not
Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types.
Wojcikiewicz, R J
The Journal of Biological Chemistry, 270, 11678-11683 (1995)
D I Yule et al.
The Journal of biological chemistry, 272(14), 9093-9098 (1997-04-04)
A key event leading to exocytosis of pancreatic acinar cell zymogen granules is the inositol 1,4,5-trisphosphate (InsP3)-mediated release of Ca2+ from intracellular stores. Studies using digital imaging microscopy and laser-scanning confocal microscopy have indicated that the initial release of Ca2+
Takahiro Fujimoto et al.
International journal of molecular medicine, 30(6), 1287-1293 (2012-09-21)
KRAS-induced actin-interacting protein (KRAP), originally identified as one of the deregulated genes expressed in colorectal cancer, participates under physiological conditions in the regulation of systemic energy homeostasis and of the exocrine system. We have recently found that KRAP is a

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