8.18203

(9-Fluorenylmethyl) chloroformate

for synthesis

• 别名: (9-Fluorenylmethyl) chloroformate, Chloroformic acid 9-fluorenylmethyl ester, FMOCCl
• 经验公式（希尔记法）: C₁₅H₁₁ClO₂
• CAS号: 28920-43-6
• 分子量: 258.70
• MDL號碼: MFCD00001138
• 分類程式碼代碼: 12352108
• 酶委員會索引編號: 249-313-6
• NACRES: NA.22

属性

• 品質等級: 200
• 形狀: powder
• mp: 60-63 °C
• 應用: peptide synthesis
• 儲存溫度: 15-25°C
• InChI: 1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2
• InChI 密鑰: IRXSLJNXXZKURP-UHFFFAOYSA-N

说明

一般說明

(9-Fluorenylmethyl) chloroformate, also known as Fmoc chloride, is a highly versatile reagent with varied applications in organic synthesis. It is most frequently used to introduce the base-labile Fmoc-protecting group to amine functionalities, particularly during the production of Fmoc-protected amino acids. Fmoc-chloride has also been used to generate mixed carboxylic and carbonic anhydrides to facilitate amide and ester bond formation. It is soluble in common organic solvents such as dichloromethane, tetrahydrofuran, and dimethylformamide.

應用

Recent applications of (9-Fluorenylmethyl) chloroformate include:

• (9-Fluorenylmethyl) chloroformate can be used as a coupling reagent.
• In the synthesis of amino acid esters. Fmoc chloride activates the carboxylic acid group of the amino acid, allowing it to react with an alcohol to form the ester.
• In the preparation of lysogangliosides.
• In the solid-phase peptide synthesis of DOPA-containing peptides.

安全信息

• 象形圖: GHS05
• 訊號詞: Danger
• 危險聲明: H314
• 防範說明: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• 危險分類: Eye Dam. 1 - Skin Corr. 1B
• 安全危害: EUH029
• 儲存類別代碼: 8A - Combustible, corrosive hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable