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Key Documents

662009

Sigma-Aldrich

U0126

InSolution, ≥98%, A potent and specific inhibitor of MEK1 and MEK2

别名:

InSolution U0126

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About This Item

经验公式(希尔记法):
C18H16N6S2 · 0.5C2H6O
分子量:
403.52
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

liquid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

運輸包裝

ambient

儲存溫度

−70°C

InChI

1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+

InChI 密鑰

DVEXZJFMOKTQEZ-JYFOCSDGSA-N

一般說明

A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.

重構

Following initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).

其他說明

Duncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett.8, 2839.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

閃點(°C)

87 °C - closed cup - (Dimethylsulfoxide)


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