565780
β-Secretase Inhibitor III
The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
别名:
β-Secretase Inhibitor III, Inhibitor GL189, H-EVNstatineVAEF-NH₂
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About This Item
经验公式（希尔记法）:
C44H70N10O14
分子量:
963.09
分類程式碼代碼:
12352200
NACRES:
NA.77
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品質等級
化驗
≥95% (HPLC)
形狀
lyophilized
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
溶解度
DMSO: 1 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
一般說明
A substrate analog inhibitor of β-secretase (BACE) that completely blocks proteolytic activity in solubilized membrane fractions of BACE-transfected MDCK cells at a concentration of 5 µM.
生化／生理作用
Cell permeable: no
Effective concentration: 5 µM completely blocking the proteolytic activity of β-secretase (BACE) in solubilized membrane fractions from BACE transfected MDCK cells
Primary Target
BACE
BACE
Product does not compete with ATP.
Reversible: no
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
H-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂
外觀
Supplied as a trifluoroacetate salt.
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他說明
Capell, A., et al. 2002. J. Biol. Chem.277, 5637.
Tung, J.S., et al. 2002. J. Med. Chem.45, 259.
Tung, J.S., et al. 2002. J. Med. Chem.45, 259.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Inmaculada Lopez-Font et al.
Molecular neurobiology, 56(12), 8603-8616 (2019-07-11)
The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the main brain β-secretase responsible for the amyloidogenic processing of the amyloid precursor protein (APP). Previous studies have suggested that cerebrospinal fluid (CSF) β-secretase activity may be a candidate diagnostic
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