565749
β-Secretase Inhibitor II
The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
别名:
β-Secretase Inhibitor II, Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
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About This Item
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品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
DMSO: 5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
一般說明
A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
A potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.
生化/生理作用
Cell permeable: yes
Primary Target
β-secretase
β-secretase
Product does not compete with ATP.
Reversible: yes
Target IC50: 700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
Z-Val-Leu-Leu-CHO
重構
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
其他說明
Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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