推荐产品
品質等級
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
white to off-white
溶解度
water: 25 mg/mL
運輸包裝
ambient
儲存溫度
10-30°C
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI 密鑰
HNDFYNOVSOOGDU-UHFFFAOYSA-N
一般說明
多粘菌素B是一种多肽抗菌药物，属于多粘菌素家族。对革兰氏阴性菌均有抑制作用，例如铜绿假单胞菌、鲍曼不动杆菌、肠杆菌、克雷伯氏菌。硫酸多粘菌素B是硫酸多粘菌素B1和硫酸多粘菌素 B2的混合物。
應用
硫酸多粘菌素B - CAS 1405-20-5 – Calbiochem已用于：
- 中和牛血清白蛋白中的内毒素
- 肝星状细胞(HSC)的体外治疗
- 作为抗生素用于大肠杆菌侧支敏感和交叉耐药分析
生化／生理作用
多粘菌素B具有抗内毒素活性。它与脂多糖(LPS)分子的脂质A结合，通过置换革兰氏阴性菌外膜的Ca2+和Mg2+促进渗透。
警告
毒性：有害（C）
其他說明
Lucas, M., et al. 1994.生物化学。Pharmacol.47, 667.
Ngezahayo, A. and Kolb, H.A.1993.Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992.J. Physiol.456, 351.
Strasser, S.H., et al. 1992.Circ.Res.70, 1304.
Hegemann, L., et al. 1991.Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991.Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990.J. Immunol.144, 662.
Ngezahayo, A. and Kolb, H.A.1993.Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992.J. Physiol.456, 351.
Strasser, S.H., et al. 1992.Circ.Res.70, 1304.
Hegemann, L., et al. 1991.Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991.Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990.J. Immunol.144, 662.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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