92283

多粘菌素B 溶液

20 mg/mL in H₂O

• 别名: Aerosporin, Polymyxin B, Polymyxin B Sulfate
• CAS号: 1405-20-5
• MDL號碼: MFCD00131991
• 分類程式碼代碼: 51283106
• NACRES: NA.85

属性

• 生物源: Bacillus polymyxa (fermentation)
• 形狀: liquid
• 光學活性: [α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
• 濃度: 20 mg/mL in H₂O
• 顏色: colorless to slightly yellow
• 溶解度: H₂O: soluble 20 mg/mL
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; fungi
• 作用方式: cell membrane | interferes
• 儲存溫度: 2-8°C
• InChI: 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
• InChI 密鑰: HNDFYNOVSOOGDU-UHFFFAOYSA-N

说明

一般說明

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa.

應用

Polymyxin B is used to study multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

生化／生理作用

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium.

Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.

包裝

10ml, 125ml

準備報告

This product is concentrated at 20 mg/mL in water, and should be stored at 2-8°C.

其他說明

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Handle and store under inert gas.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves