81271

多粘菌素B 溶液

1 mg/mL in H₂O, analytical standard

• CAS号: 1405-20-5
• MDL號碼: MFCD00131991
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: analytical standard
• 品質等級: 100
• 濃度: 1 mg/mL in H₂O
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; fungi
• 應用: pharmaceutical (small molecule)
• 格式: single component solution
• 作用方式: cell membrane | interferes
• 儲存溫度: 2-8°C
• InChI: 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
• InChI 密鑰: HNDFYNOVSOOGDU-UHFFFAOYSA-N

说明

一般說明

Chemical structure: peptide

Polymyxin B solution can find therapeutic applications as an antimicrobial agent, since it shows activity against multidrug-resistant (MDR) gram-negative bacterial infections.

應用

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化／生理作用

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium.

Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.

準備報告

This product is concentrated at 1 mg/mL in water, and should be stored at 2-8°C.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves