528824

PARP Inhibitor XIV

The PARP Inhibitor XIV, also referenced under CAS 1104546-89-5, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 别名: PARP Inhibitor XIV, 4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165
• 经验公式（希尔记法）: C₁₅H₁₂N₂O₂
• CAS号: 1104546-89-5
• 分子量: 252.27
• MDL號碼: MFCD12912397
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥97% (sum of two isomers, HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: orange
• 溶解度: DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9-
• InChI 密鑰: BTYSIDSTHDDAJW-LCYFTJDESA-N

说明

一般說明

A cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC₅₀ = 7.35; IC₅₀ = 45 nM) in a NAD⁺-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Eltze, T., et al. 2008. Mol. Pharmacol.74, 1587.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable