493800

PARP Inhibitor VI, NU1025

The PARP Inhibitor VI, NU1025, also referenced under CAS 90417-38-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 别名: PARP Inhibitor VI, NU1025, 8-Hydroxy-2-methylquinazoline-4-one
• 经验公式（希尔记法）: C₉H₈N₂O₂
• CAS号: 90417-38-2
• 分子量: 176.17
• MDL號碼: MFCD00942555
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 25 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)
• InChI 密鑰: YJDAOHJWLUNFLX-UHFFFAOYSA-N

说明

一般說明

A potent inhibitor poly(ADP-ribose) polymerase (PARP; IC₅₀ = 0.40 µM). Has been shown to potentiate the cytotoxicity of the DNA-methylating agent MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide] and ionizing irradiation in murine L210 leukemia cells.

A potent poly(ADP-ribose) polymerase (PARP) inhibitor (IC₅₀ = 400 nM) that potentiates the cytotoxicity of various DNA-active agents, including the DNA-methylating compound MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide], the DNA strand break-inducing drug temozolomide, topotecan, bleomycin, and ionizing radiation in murine L1210 leukemia cells, Chinese hamster ovary cells, and in a variety of human tumor cell lines.

生化／生理作用

Cell permeable: no

Primary Target
PARP

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 0.4 µM against poly(ADP-ribose) polymerase (PARP)

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

準備報告

This solution can be further diluted 1:100 in tissue culture medium before use.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Delaney, C.A., et al. 2000. Clin. Cancer Res.6, 2860.
Boulton, S., et al. 1999. Carcinogenesis20, 199.
Bowman, K.J., et al. 1998. Br. J. Cancer 78, 1269.
Griffin, R.J., et al. 1998. J. Med. Chem. 41, 5247.
Griffin, R.J., et al. 1996. Pharm. Sci. 2, 43.
Boulton, S., et al. 1995. Br. J. Cancer 72, 849.
Griffin, R.J., et al. 1995. Anticancer Drug Res. 10, 507.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3