324473

PARP Inhibitor IX, EB-47

The PARP Inhibitor IX, EB-47 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 别名: PARP Inhibitor IX, EB-47
• 经验公式（希尔记法）: C₂₄H₂₇N₉O₆ · 2HCl · 2H₂O
• 分子量: 646.48
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 效力: 45 nM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: white
• 溶解度: water: 50 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C

说明

一般說明

A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of PARP-1 (IC₅₀ = 45 nM). Shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.

A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) (IC₅₀ = 45 nM). Reported to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.

生化／生理作用

Cell permeable: yes

Primary Target
PARP-1

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

重構

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett.14, 81.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable