525185

Phospholipase C Activator, m-3M3FBS

The Phospholipase C Activator, m-3M3FBS, also referenced under CAS 200933-14-8, controls the biological activity of Phospholipase C. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

• 别名: Phospholipase C Activator, m-3M3FBS, m-3M3FBS, 2,4,6-Trimethyl-N-( m-3-trifluoromethylphenyl)benzenesulfonamide, m-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
• 经验公式（希尔记法）: C₁₆H₁₆F₃NO₂S
• CAS号: 200933-14-8
• 分子量: 343.36
• MDL號碼: MFCD00095824
• 分類程式碼代碼: 51111800
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 7 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3
• InChI 密鑰: ZIIUUSVHCHPIQD-UHFFFAOYSA-N

说明

一般說明

A cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca²⁺ release, inositol phosphate production, and superoxide generation in various cell types. Activates all PLC isotypes (β2, β3, γ1, &gamma2, and δ1) in vitro, but does not exhibit any effect on heterotrimeric G proteins, PI 3-kinase, or phospholipase D.

A novel sulfonamide compound that acts as a cell-permeable and specific activator of phospholipase C (PLC). Shown to stimulate the PLC-mediated intracellular Ca²⁺ release, inositol phosphates production, and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2, and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase, or PLD.

生化／生理作用

Cell permeable: yes

Primary Target
Phospholipase C (PLC)

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

其他說明

Bae, Y.S., et al. 2003. Mol. Pharmacol.63, 1043.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable