推荐产品
产品名称
MMP-12抑制剂,MMP408, The MMP-12 Inhibitor, MMP408, also referenced under CAS 1258003-93-8, controls the biological activity of MMP-12. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
品質等級
化驗
≥94% (HPLC)
形狀
solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
off-white
溶解度
DMSO: 100 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
一般說明
一种二苯并呋喃基磺酰胺基缬氨酸化合物,可作为有效的活性位点锌靶向MMP-12选择性抑制剂(对人MMP-12的IC50 =2 nM),对小鼠/大鼠/绵羊物种的MMP-12(分别为IC50=160、320和22.3 nM)或人MMP-3/13/14(分别为IC50=351、120和1100 nM)的活性弱得多,并且对人Agg-1/2(IC50 >5 µM),TACE(IC50 >25 µM)和MMP-1/7(IC50 >6 µM)几乎无效。MMP408在小鼠中具有口服活性,并显示可有效减轻rhMMP-12诱导的小鼠体内肺组织炎症反应超过50%(5 mg/kg,p.o.,b.i.d.)。
包裝
用惰性气体包装
警告
毒性:标准处理(A)
重構
复溶后,等分并冷冻保存(-20°C)。贮备液在-20°C下可稳定保存至多3个月。
其他說明
Li, W., et al. 2009.J. Med. Chem.52, 1799.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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