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Merck
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主要文件

444291

Sigma-Aldrich

MMP408

≥94% (HPLC), solid, MMP-12 inhibitor, Calbiochem®

别名:

MMP-12抑制剂,MMP408, (S)-2-(8-(甲氧基羰基氨基)二苯并[b,d]呋喃-3-磺酰胺基)-3-甲基丁酸

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About This Item

经验公式(希尔记法):
C19H20N2O7S
分子量:
420.44
分類程式碼代碼:
12352200
NACRES:
NA.77

产品名称

MMP-12抑制剂,MMP408, The MMP-12 Inhibitor, MMP408, also referenced under CAS 1258003-93-8, controls the biological activity of MMP-12. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

品質等級

化驗

≥94% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

off-white

溶解度

DMSO: 100 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

一般說明

一种二苯并呋喃基磺酰胺基缬氨酸化合物,可作为有效的活性位点锌靶向MMP-12选择性抑制剂(对人MMP-12的IC50 =2 nM),对小鼠/大鼠/绵羊物种的MMP-12(分别为IC50=160、320和22.3 nM)或人MMP-3/13/14(分别为IC50=351、120和1100 nM)的活性弱得多,并且对人Agg-1/2(IC50 >5 µM),TACE(IC50 >25 µM)和MMP-1/7(IC50 >6 µM)几乎无效。MMP408在小鼠中具有口服活性,并显示可有效减轻rhMMP-12诱导的小鼠体内肺组织炎症反应超过50%(5 mg/kg,p.o.,b.i.d.)。

包裝

用惰性气体包装

警告

毒性:标准处理(A)

重構

复溶后,等分并冷冻保存(-20°C)。贮备液在-20°C下可稳定保存至多3个月。

其他說明

Li, W., et al. 2009.J. Med. Chem.52, 1799.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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