361555

GSK-3 Inhibitor XIII

The GSK-3 Inhibitor XIII, also referenced under CAS 404828-08-6, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 别名: GSK-3 Inhibitor XIII, (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine
• 经验公式（希尔记法）: C₁₈H₁₅N₅
• CAS号: 404828-08-6
• 分子量: 301.35
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C18H15N5/c1-12-11-16(23-22-12)20-18-14-9-5-6-10-15(14)19-17(21-18)13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20,21,22,23)
• InChI 密鑰: JYCUVOXSZBECAY-UHFFFAOYSA-N

说明

一般說明

A potent and ATP-competitive inhibitor of GSK-3 (K_i = 24 nM).

An aminopyrazole compound that acts as a potent and ATP-binding site inhibitor of GSK-3 with a K_i of 24 nM.

生化／生理作用

Cell permeable: no

Primary Target
GSK-3

Product does not compete with ATP.

Reversible: no

Target K_i: 24 nM against GSK-3

警告

Toxicity: Carcinogenic / Teratogenic (D)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Pierce, A.C., et al. 2005. J. Med. Chem.48, 1278.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1