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生物源
human
品質等級
重組細胞
expressed in baculovirus infected Sf21 cells
產品線
Upstate®
比活性
(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
分子量
Mw 39.9 kDa
純化經由
(Ni2+/NTA-agarose)
物種活性
human
製造商／商標名
Upstate®
技術
activity assay: suitable (kinase)
登錄號
(FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K. )
NM_000215.2
NCBI登錄號
UniProt登錄號
一般說明
N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end
應用
Research Category
Inflammation & Immunology
Inflammation & Immunology
生化／生理作用
Protein Target: JAK3
Target Sub-Family: TK
包裝
Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-629M when ordering the 250 µg size.
品質
routinely evaluated by phosphorylation of 500μM JAK3tide (Catalog # 12-547)
標靶描述
JAK3
外觀
Ni2+/NTA-agarose
儲存和穩定性
6 months at -70°C
其他說明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°C）
Not applicable
B A Witthuhn et al.
Nature, 370(6485), 153-157 (1994-07-14)
Many cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies have shown that one or more of the Janus kinase family
J A Johnston et al.
Nature, 370(6485), 151-153 (1994-07-14)
Interleukin-2 is an autocrine growth factor for T cells which also activates other cells including B cells and natural killer cells. The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event
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