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Merck

700051P

Avanti

22(S)-hydroxycholesterol-d7

Avanti Research - A Croda Brand

别名:

25,26,26,26,27,27,27-heptadeuterocholest-5-ene-3β,22S-diol

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About This Item

经验公式(希尔记法):
C27H39O2D7
分子量:
409.70
分類程式碼代碼:
41141804
NACRES:
NA.25

描述

cholest-5-ene-3β,22(S)-diol-d7

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (700051P-1mg)

製造商/商標名

Avanti Research - A Croda Brand

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

22(S)-hydroxycholesterol is an enantiomer of 22(R)-hydroxycholesterol. 22(S)-hydroxycholesterol-d7 is a deuterated form of 22(S)-hydroxycholesterol.

應用

22(S)-hydroxycholesterol-d7 may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma low-density lipoprotein (LDL).

生化/生理作用

22(S)-hydroxycholesterol (22(S)-HC) promotes glucose catabolism and uptake and is regarded as a potential target to treat type 2 diabetes. 22(S)-HC also prevents the accumulation of lipids and lipid synthesis in hepatocytes and myotubes. Unlike 22(R)-hydroxycholesterol, 22(S)-HC is not estrogenic and is not a ligand for liver X receptor (LXR).

包裝

5 mL Amber Glass Screw Cap Vial (700051P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids


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Hiroyoshi Sato et al.
Bioscience, biotechnology, and biochemistry, 68(8), 1790-1793 (2004-08-24)
In order to test the estrogenic activity of sterol oxidation products from cholesterol and phytosterols, an estrogen-dependent gene expression assay was performed in estrogen receptor alpha-stably transformed HeLa cells. The ranking of the estrogenic potency of these compounds was different:

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