跳转至内容
Merck
所有图片(1)

Key Documents

View All Documentation

934208

Sigma-Aldrich

NanoFabTx™ DBCO Lipid Mix

for synthesis of DBCO-functionalized liposomes

登录查看公司和协议定价
所有图片(1)

About This Item

分類程式碼代碼:
12161503
NACRES:
NA.28

品質等級

100

儲存溫度

−20°C

相关类别

應用

NanoFabTx™ DBCO Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of DBCO-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.

This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with DBCO groups using extrusion and microfluidics are also included. The synthesized DBCO-functionalized liposomes enable the conjugation of azide-tagged antibodies or proteins to the liposomes surface for immunothereapy applications and multi-targeting or multi-type cargo delivery.

特點和優勢

  • A ready-to-use nanoformulation lipid blend for the synthesis of DBCO-functionalized liposomes
  • Step-by-step extrusion and microfluidics protocols for liposome synthesis developed and tested by our formulation scientists
  • Flexible synthesis methods to create uniform and reproducible liposomes
  • Protocols and lipid blend optimized to make liposomes around 100 nm diameter with low polydispersity
  • Lipid mix optimized for azide-tagged protein or antibody conjugation and small molecule encapsulation
Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

For more information, please refer to the protocol under the Protocol section of this page.

法律資訊

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number

抱歉，我们目前尚未线上提供该产品的COA。

如需帮助，请联系 客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Daxing Liu et al.
Scientific reports, 12(1), 10564-10564 (2022-06-23)
Given our interest in the utility of liposomes for molecular imaging and theranostics, we investigated how coating the outer layer of the liposome affects internalization by breast cancer cell lines in vitro and in breast tumor tissues in vivo. Indeed

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门