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Merck

761540

Sigma-Aldrich

二苯并环辛炔胺

for Copper-free Click Chemistry

别名:

DBCO-NH2, DBCO胺

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About This Item

经验公式(希尔记法):
C18H16N2O
分子量:
276.33
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.22

品質等級

形狀

solid

反應適用性

reaction type: click chemistry
reagent type: linker

mp

86-96 °C

官能基

amine

儲存溫度

−20°C

SMILES 字串

NCCC(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O

InChI

1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2

InChI 密鑰

OCCYFTDHSHTFER-UHFFFAOYSA-N

一般說明

二苯并环辛炔胺(DBCO-NH2) 是一种杂官能团连接剂,含有一个DBCO结构单元,该结构单元常用于纳米抗体(nanobodies )的位点特异性官能化,促进随后的点击化学反应中反应性DBCO基团的引入。

應用

二苯并环辛炔胺可用作:
  • 连接含叠氮化物官能团的连接剂。它通过应变促进的叠氮化物-炔烃环加成反应(SPAAC)促进键的形成
  • 合成氮杂环卡宾金属硫醇盐的试剂。它使金属复合物官能化,增加应变促进的炔烃–叠氮化物环加成(SPAAC) 反应的反应活性
  • 胺官能化环辛炔衍生物。环辛炔可用于菌株促进的无铜叠氮化物-炔烃环加成反应。该二苯并环辛炔可在不需要Cu(I)催化剂的情况下,与叠氮官能化化合物或生物分子反应,以产生稳定的三唑键。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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商品

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.

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