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Merck

906794

Bis(neopentyltrimethylammonium) oxalate

别名:

N,N,N,2,2-Pentamethylpropan-1-aminium oxalate, Bis(trimethylneopentylammonium) oxalate

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About This Item

经验公式(希尔记法):
C18H40N2O4
分子量:
348.52

形狀

powder, crystals or chunks

儲存溫度

−20°C

應用

This bis(neopentyltrimethylammonium) oxalate is used in the elution step of the Ritter lab′s new method for deoxyfluorination of phenols. First, an Fmoc-protected ruthenium tyrosine amino acid derivative ([CpRu(Fmoc-tyrosin)]CF3CO2, cat# 902314) is incorporated to a peptide. Later, bis(neopentyltrimethylammonium) oxalate and chloroimidazolium chloride (cat# 904848) facilitate the elution of [18F]fluoride. The final [18F]fluoride radiolabeled polypeptide is useful in positron emission tomography (PET) imaging for the study of various biological applications.

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注意

Bis(neopentyltrimethylammonium) oxalate is hygroscopic and should be stored in a closed vial or in a desiccator.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Jens Rickmeier et al.
Angewandte Chemie (International ed. in English), 57(43), 14207-14211 (2018-09-07)
Radiolabeled receptor-binding peptides are an important class of positron emission tomography tracers owing to achievable high binding affinities and their rapid blood clearance. Herein, a method to introduce a 4-[18 F]fluoro-phenylalanine residue into peptide sequences is reported, by chemoselective radio-deoxyfluorination

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