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Merck

767344

Sigma-Aldrich

Poly(D,L-lactide)

average Mn 20,000 (NMR), PDI ≤1.3

别名:

PDLA, PLA, polyDL-lactide

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About This Item

分類程式碼代碼:
12162002
NACRES:
NA.23

形狀

crystals

品質等級

分子量

average Mn 20,000 (NMR)

降解時間

<6 months

mp

320-350 °C

蛋白質二硫鍵異構酶

≤1.3

儲存溫度

2-8°C

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應用

Used in Drug Delivery including coating nanoparticles. Can be end-group functionalizated or used as a macroinitiator/block precursor.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

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Synthesis of Shape Amphiphiles Based on Functional Polyhedral Oligomeric Silsesquioxane End-Capped Poly(L-Lactide) with Diverse Head Surface Chemistry
Zhang W B, et al.
Macromolecules, 44(8), 2589-2596 (2011)
Poly(lactide)-block-Poly(HEMA) Block Copolymers: An Orthogonal One-Pot Combination of ROP and ATRP, Using a Bifunctional Initiator
Wolf F F, et al.
Macromolecules, 42(15), 5622-5628 (2009)
Preparation of Protein-Loaded Poly(L-Lactide) Microspheres by Solution-Enhanced Dispersion by Supercritical CO2
Chen A Z, et al.
Journal of Biomimetics, Biomaterials, and Tissue Engineering, 11, 93-100 (2011)

商品

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

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