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Merck

662534

Sigma-Aldrich

4-巯基苯甲酸

technical grade, 90%

别名:

4-巯基苯甲酸, 对巯基苯甲酸

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About This Item

线性分子式:
HSC6H4CO2H
CAS号:
分子量:
154.19
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

等級

technical grade

品質等級

化驗

90%

形狀

solid

mp

215-224 °C (lit.)

SMILES 字串

OC(=O)c1ccc(S)cc1

InChI

1S/C7H6O2S/c8-7(9)5-1-3-6(10)4-2-5/h1-4,10H,(H,8,9)

InChI 密鑰

LMJXSOYPAOSIPZ-UHFFFAOYSA-N

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一般說明

4-Mercaptobenzoic acid (4-MBA), also known as 4-Carboxythiophenol or p-Mercaptobenzoic acid, is an aromatic compound used in organic synthesis. 4-MBA promotes the formation of disulfide bonds through its reactive thiol (-SH) group. The sulfur atom in the thiol group is highly nucleophilic, allowing it to attack electrophiles.  facilitates the formation of diverse thiol-containing compounds.  Additionally, 4-MBA serves as a ligand to form coordination complexes and is utilized for surface functionalization, particularly in creating self-assembled monolayers (SAMs) on metal surfaces.

應用

  • 食品掺假检测的SERS底物:采用4-巯基苯甲酸通过生物聚合物层层组装,原位制造AuNP等离子体纸,可作为表面增强拉曼散射(SERS)基底用于食品掺假检测(Viriyakitpattana et al., 2024)。
  • 磁性-等离子体纳米粒子的开发:结合激光烧蚀和溶剂热法获得磁性-等离子体纳米粒子,可用于4-巯基苯甲酸为标记分子的多波长SERS。说明纳米颗粒合成的多样性(Talaikis et al., 2023)。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

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Molly K Gregas et al.
Applied spectroscopy, 64(8), 858-866 (2010-08-20)
We describe the development and application of a co-functionalized nanoprobe and biodelivery platform combining a nuclear targeting peptide (NTP) for improved cellular uptake and intracellular targeting with p-mercaptobenzoic acid (pMBA) as a surface-enhanced Raman scattering (SERS) reporter for tracking and
Wen-Tsen Chen et al.
Journal of the American Society for Mass Spectrometry, 21(5), 864-867 (2010-02-23)
We have developed a new internal standard method for the determination of the concentration of captopril (CAP) through surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using gold nanoparticles (Au NPs). This approach provided linearity for CAP over the concentration range 2.5-25
Aleksandra Jaworska et al.
The Analyst, 140(7), 2321-2329 (2014-12-09)
The intracellular pH plays an important role in various cellular processes. In this work, we describe a method for monitoring of the intracellular pH in endothelial cells by using surface enhanced Raman spectroscopy (SERS) and 4-mercaptobenzoic acid (MBA) anchored to
Fenglin Wang et al.
Analytical chemistry, 84(18), 8013-8019 (2012-08-14)
Sensors based upon surface-enhanced Raman spectroscopy (SERS) are attractive because they have narrow, vibrationally specific spectral peaks that can be excited using red and near-infrared light which avoids photobleaching, penetrates tissue, and reduces autofluorescence. Several groups have fabricated pH nanosensors
Garima Gupta et al.
Biosensors & bioelectronics, 36(1), 95-102 (2012-04-27)
Surface plasmon resonance (SPR) immunosensor using 4-mercaptobenzoic acid (4-MBA) modified gold SPR chip was developed first time for the detection of flagellin specific antibodies of Salmonella typhi (S. typhi). Flagellin protein of S. typhi was prepared by recombinant DNA technology.

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