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Merck

47633

Sigma-Aldrich

N-(9-芴甲氧羰基)-L-亮氨酸

≥97.0%

别名:

N-(9-芴甲氧羰基)-L-亮氨酸, Fmoc-L-亮氨酸

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About This Item

经验公式(希尔记法):
C21H23NO4
CAS号:
分子量:
353.41
Beilstein:
2178254
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.26

品質等級

化驗

≥97.0%

光學活性

[α]20/D −25±2°, c = 1% in DMF

反應適用性

reaction type: C-H Activation
reaction type: Fmoc solid-phase peptide synthesis
reagent type: ligand
reaction type: Peptide Synthesis

mp

152-156 °C (lit.)
152-156 °C

應用

peptide synthesis

官能基

Fmoc
amine
carboxylic acid

儲存溫度

2-8°C

SMILES 字串

CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1

InChI 密鑰

CBPJQFCAFFNICX-IBGZPJMESA-N

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應用

Fmoc-Leu-OH可用作合成反应剂:
  • 通过与功能化α-氨基酸盐酸盐反应合成寡肽。
  • 环酯Sansalvamide A,这是在海洋真菌中发现的一种天然产物。
  • Streptocidin A−D,放线菌Tü 6071中天然存在的十肽抗生素。
  • 酰基二肽酰胺,可用于化妆品应用。

生化/生理作用

可诱导胰岛素敏感化,但不能诱导脂肪生成的 PPARγ 配体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

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Markus Beck Erlach et al.
Journal of biomolecular NMR, 69(2), 53-67 (2017-09-16)
For evaluating the pressure responses of folded as well as intrinsically unfolded proteins detectable by NMR spectroscopy the availability of data from well-defined model systems is indispensable. In this work we report the pressure dependence of
M J Miller et al.
The Journal of pharmacology and experimental therapeutics, 266(1), 468-472 (1993-07-01)
Anti-inflammatory properties have been ascribed to a series of N-(fluorenyl-9-methoxycarbonyl) amino acids called leumedins that inhibit the activity of granulocytes and T-lymphocytes. We evaluated one of these leumedins, N-(fluorenyl-9-methoxycarbonyl) leucine (NPC 15199), in a model of ileitis in guinea pigs.
C R Jan et al.
The Chinese journal of physiology, 43(1), 29-33 (2000-06-17)
This report demonstrates that NPC-15199 [(N-(9-fluorenylmethoxycarbonyl)L-leucine)], a novel anti-inflammatory agent, increases intracellular Ca2+ concentration ([Ca2+]i) in human bladder female transitional cancer (BFTC) cells. Using fura-2 as a Ca2+ probe, NPC-15199 (0.1-2 mM) was found to increase [Ca2+]i concentration-dependently. The response
Zhimou Yang et al.
Chemical communications (Cambridge, England), (35)(35), 4414-4416 (2005-09-02)
Two types of therapeutic agents, which have discrete yet complementary functions, self-assemble into nanofibers in water to formulate a new supramolecular hydrogel as a self-delivery biomaterial to reduce the toxicity of uranyl oxide at the wound sites.
Facile solid-phase synthesis of cyclic decapeptide antibiotic streptocidins A-D
Qin C, et al.
Tetrahedron Letters, 45(1), 217-220 (2004)

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With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

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