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531480

Sigma-Aldrich

N-芴甲氧羰基-L-丙氨酸

95%, for peptide synthesis

别名:

N-芴甲氧羰基-L-丙氨酸, Fmoc-L-丙氨酸

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About This Item

经验公式（希尔记法）:
C18H17NO4
CAS号:
35661-39-3
分子量:
311.33
Beilstein:
2225975
EC號碼:
252-660-6
MDL號碼:
MFCD00037139
分類程式碼代碼:
12352209
PubChem物質ID:
24877820
NACRES:
NA.26

产品名称

N-芴甲氧羰基-L-丙氨酸, 95%

化驗

95%

光學活性

[α]20/D −18°, c = 1 in DMF

反應適用性

reaction type: C-H Activation
reaction type: Fmoc solid-phase peptide synthesis
reagent type: ligand
reaction type: Peptide Synthesis

mp

147-153 °C (lit.)

應用

peptide synthesis

官能基

Fmoc
amine
carboxylic acid

儲存溫度

2-8°C

SMILES 字串

C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C18H17NO4/c1-11(17(20)21)19-18(22)23-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,11,16H,10H2,1H3,(H,19,22)(H,20,21)/t11-/m0/s1

InChI 密鑰

QWXZOFZKSQXPDC-NSHDSACASA-N

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相关类别

一般說明

Fmoc-Ala-OH又称为Fmoc-L-丙氨酸, 在Fmoc固相肽合成中起多种作用。

應用

Fmoc-Ala-OH的一般用途：
  • 作为制备三唑肽和氮杂肽的构件
  • 通过标准Fmoc固相肽合成法合成双阳离子卟啉肽
  • 不经过氮杂环丙烷化作用，将曼尼希加合物转化为α-卤化酰胺

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
STBK8567
STBK8241
STBK1840
STBJ8127
STBJ0464

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Fabian Schnitter et al.
Nature protocols, 16(8), 3901-3932 (2021-07-02)
Many supramolecular materials in biological systems are driven to a nonequilibrium state by the irreversible consumption of high-energy molecules such as ATP or GTP. As a result, they exhibit unique dynamic properties such as a tunable lifetime, adaptivity or the
Xue Zhi Zhao et al.
Molecules (Basel, Switzerland), 23(8) (2018-07-28)
HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions. However, the emergence of IN mutants
Leixia Mei et al.
Organic & biomolecular chemistry, 17(4), 939-944 (2019-01-11)
We report the synthesis and self-assembly of fluorescent peptide amphiphiles (NBD-PA) composed of a fluorescent NBD probe and a peptide derivative VVAADD with a C12-alkyl-chain as the linker (NBD-C12-VVAADD). The self-assembly of NBD-PA formed beta-sheet structures at neutral pH in
Devi Wahyuningtyas et al.
Chembiochem : a European journal of chemical biology, 20(16), 2133-2140 (2019-06-06)
Huntington's disease (HD) is classified as a protein-misfolding disease correlated with the mutant Huntingtin (mHtt) protein with abnormally expanded polyglutamine (polyQ) domains. Because no effective drugs have yet been reported, attempts to develop better therapy to delay the age of
R Ashton Lavoie et al.
International journal of molecular sciences, 20(7) (2019-04-11)
The growing integration of quality-by-design (QbD) concepts in biomanufacturing calls for a detailed and quantitative knowledge of the profile of impurities and their impact on the product safety and efficacy. Particularly valuable is the determination of the residual level of
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