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品質等級
化驗
98%
形狀
solid
mp
142-144 °C (lit.)
官能基
carboxylic acid
fluoro
nitro
SMILES 字串
OC(=O)c1cc(ccc1F)[N+]([O-])=O
InChI
1S/C7H4FNO4/c8-6-2-1-4(9(12)13)3-5(6)7(10)11/h1-3H,(H,10,11)
InChI 密鑰
ICXSHFWYCHJILC-UHFFFAOYSA-N
一般說明
2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product.
應用
2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:
- dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support
- synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols
- in the synthesis of oxazepines
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Wim Meutermans et al.
ChemMedChem, 1(11), 1164-1194 (2006-09-20)
Drug discovery has long suffered from the difficulty of having to place pharmacophoric groups in just the right spatial arrangement to elicit the desired biological response. Although some molecule classes have been discovered that seem to be privileged structures for
MCC/SN Ar methodology. Part 2: Novel three-step solution phase access to libraries of benzodiazepines.
Tempest P, et al.
Tetrahedron Letters, 44(9), 1947-1950 (2003)
Efficient approach for the diversity-oriented synthesis of macro-heterocycles on solid-support.
Giulianotti M and Nefzi A.
Tetrahedron Letters, 44(28), 5307-5309 (2003)
Solid support synthesis of 2-substituted dibenz [b, f] oxazepin-11 (10H)-ones< i> via</i> S< sub> N</sub> Ar methodology on AMEBA resin.
Ouyang X, et al.
Tetrahedron, 55(10), 2827-2834 (1999)
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