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About This Item
线性分子式:
(C6H5)3CSCH2CH(NH2)CO2H
CAS号:
分子量:
363.47
Beilstein:
2339626
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.22
推荐产品
product name
(+)-S-三苯甲基-L-半胱氨酸, 97%
化驗
97%
光學活性
[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl
反應適用性
reaction type: solution phase peptide synthesis
mp
182-183 °C (dec.) (lit.)
應用
peptide synthesis
SMILES 字串
N[C@@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)C(O)=O
InChI
1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1
InChI 密鑰
DLMYFMLKORXJPO-FQEVSTJZSA-N
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應用
(+)-S-三苯甲基 -L-半胱氨酸是一种非天然的含硫氨基酸，通常用作液相多肽合成（SPPS）中的溶剂。它还可用作金属结合剂，用于以 HBTU 肽偶联剂通过肽-金属相互作用合成可用于阳离子传感应用解决方案的取代的二茂铁酰肽偶联物。
其他客户在看
Sébastien Brier et al.
Journal of molecular biology, 360(2), 360-376 (2006-06-20)
The mitotic kinesin Eg5 plays an essential role in establishing the bipolar spindle. Recently, several antimitotic inhibitors have been shown to share a common binding region on Eg5. Considering the importance of Eg5 as a potential drug target for cancer
James A D Good et al.
Journal of medicinal chemistry, 56(5), 1878-1893 (2013-02-12)
The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved potency, favorable drug-like properties, but
Frank Kozielski et al.
Proteomics, 8(2), 289-300 (2008-01-11)
Mitotic kinesins represent potential drug targets for anticancer chemotherapy. Inhibitors of different chemical classes have been identified that target human Eg5, a kinesin responsible for the establishment of the bipolar spindle. One potent Eg5 inhibitor is S-trityl-L-cysteine (STLC), which arrests
Total synthesis of didmolamides A and B
You Shu-Li and Kelly JW
Tetrahedron Letters, 46(15), 2567-2570 (2005)
Daniel B Nichols et al.
European journal of medicinal chemistry, 49, 191-199 (2012-01-28)
Structure-based studies led to the identification of a constrained derivative of S-trityl-l-cysteine (STLC) scaffold as a candidate inhibitor of hepatitis C virus (HCV) NS5B polymerase. A panel of STLC derivatives were synthesized and investigated for their activity against HCV NS5B.
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