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Merck

144436

Sigma-Aldrich

异丁酰胺

99%

别名:

2-甲基丙酰胺

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About This Item

线性分子式:
(CH3)2CHCONH2
CAS号:
分子量:
87.12
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

99%

形狀

solid

bp

216-220 °C (lit.)

mp

127-131 °C (lit.)

密度

1.013 g/mL at 25 °C (lit.)

官能基

amide

SMILES 字串

CC(C)C(N)=O

InChI

1S/C4H9NO/c1-3(2)4(5)6/h3H,1-2H3,(H2,5,6)

InChI 密鑰

WFKAJVHLWXSISD-UHFFFAOYSA-N

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應用

异丁酰胺在合成过程中用于人血清白蛋白的化学接枝序列组装蛋白胶囊

生化/生理作用

异丁酰胺激活人 γ-珠蛋白基因和鼠胚胎 ε(y)-珠蛋白基因的转录 。它可用于治疗 β-地中海贫血和镰状细胞病

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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J Zhang et al.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 16(4), 187-193 (2003-08-09)
To examine the effect of isobutyramide synthesized in our laboratory on human and murine globin gene expression and to test cell toxicity of the drug. MEL cells were transfected with the recombinant construct muLCRAgammapsibetadeltabeta and the stable transformants were cultured
S P Perrine et al.
The American journal of pediatric hematology/oncology, 16(1), 67-71 (1994-02-01)
Stimulating expression of the normal fetal globin genes is a preferred method of ameliorating sickle cell disease and beta-thalassemia for the majority of patients in North America who do not have appropriate bone marrow donors. Due to increased survival of
G B Strambini et al.
Biochemistry, 29(1), 203-208 (1990-01-09)
The phosphorescence properties of liver alcohol dehydrogenase from horse were characterized at limiting concentrations of coenzyme and coenzyme analogues. The emission decay kinetics of Trp-314 in strong, slowly exchanging, ternary complexes with NADH/isobutyramide, NAD/pyrazole, and NADH/dimethyl sulfoxide displays a markedly
M D Cappellini et al.
Annals of the New York Academy of Sciences, 850, 110-119 (1998-07-21)
The aims of this study were to ascertain tolerability, safety and efficacy of oral isobutyramide (150 mg/kg bw/day) in stimulating fetal hemoglobin production in twelve thalassemia intermedia patients. Patients were treated for 28 days and followed for a further 28
Thermosensitive molecular assemblies from poly(amidoamine) dendron-based lipids.
Kenji Kono et al.
Angewandte Chemie (International ed. in English), 50(28), 6332-6336 (2011-05-21)

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