SAB4502906

Anti-Synaptophysin antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : major synaptic vesicle protein p38, synaptophysin
• Numéro MDL: MFCD00164741
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 33 kDa
• Espèces réactives: mouse, rat, human
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Numéro d'accès NCBI: P08247
• Numéro d'accès UniProt: P08247
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... SYP(6855)

Description

Description générale

Synaptophysin (SYP) is an integral membrane protein of synaptic vesicles. It is expressed in cortical synaptic terminals, during neurogenesis. The gene is located on human chromosome Xp11.23.

Synaptophysin is an integral membrane glycoprotein that is localized in presynaptic vesicles of nerve cells. This protein may regulate exocytosis and the formation of synaptic vesicles . Synaptophysin is encoded by the SYP gene and genetic alterations in SYP can lead to mental retardation . Anti-synaptophysin antibody specifically detects endogenous levels of total synaptophysin protein.

Immunogène

The antiserum was produced against synthesized peptide derived from human Synaptophysin.

Immunogen Range: 101-150

Application

Anti-Synaptophysin antibody produced in rabbit has been used in:

• immunocytochemistry
• western blotting
• immunohistochemistry

Anti-synaptophysin antibody is suitable for use in immunohistochemistry and western blot.

Actions biochimiques/physiologiques

Synaptophysin (SYP) modulates neurotransmitter release and synaptic plasticity. It maintains biogenesis and recycling of synaptic vesicles. SYP functions as a marker for neuroendocrine tumors. It is used as a potent marker for neuroendocrine prostate cancer (NEPC). Mutations in this gene is associated with X-linked intellectual disability.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable