S5768

Monoclonal Anti-Synaptophysin antibody produced in mouse

clone SVP-38, ascites fluid

• Synonyme(s) : Synaptophysin Antibody, Synaptophysin Antibody - Monoclonal Anti-Synaptophysin antibody produced in mouse
• Numéro MDL: MFCD00164741
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: ascites fluid
• Type de produit anticorps: primary antibodies
• Clone: SVP-38, monoclonal
• Poids mol.: antigen 38 kDa
• Contient: 15 mM sodium azide
• Espèces réactives: pig, rat, human, guinea pig
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; immunohistochemistry (frozen sections): 1:200 using rat cerebellum; indirect ELISA: suitable; western blot: suitable
• Isotype: IgG1
• Numéro d'accès UniProt: P08247
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... SYP(6855) ; rat ... Syp(24804)

Description

Description générale

Synaptophysin (SYP) is an integral membrane glycoprotein of 38,000 Da and it has four membrane-spanning domains. Synaptophysin is localized to neurons, neuromuscular junctions, paraganglia cells, hypophysis, pancreatic islet cells, and adrenal cells. SYP gene is mapped to human chromosome Xp11.23. Monoclonal Anti-Synaptophysin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Spécificité

Labels synaptophysin in neurons, neuromuscular junctions, benign and malignant neural tumors, paraganglia cells, hypophysis, pancreatic islet cells, and adrenal cells.

Immunogène

Rat retina synaptosome.

Application

Monoclonal Anti-Synaptophysin antibody has been used in western blotting.

Actions biochimiques/physiologiques

Synaptophysin participates in calcium dependent exocytosis. The antibody detects synaptophysin in many types of benign and malignant neural and epithelial neuroendocrine neoplasms. It is widely used as a potential marker to study the circulation of synapses in the brain and to discover the basic features of the life cycle of synaptic vesicles (SVs).

Forme physique

Monoclonal Anti-Synaptophysin is provided as ascites fluid containing 0.1% sodium azide.

Stockage et stabilité

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable