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1535008

USP

Phenytoin

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

5,5-Diphenylhydantoin, 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin

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About This Item

Fórmula empírica (notación de Hill):
C15H12N2O2
Número de CAS:
57-41-0
Peso molecular:
252.27
Beilstein:
384532
Número MDL:
MFCD00005264
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329750826
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

phenytoin

fabricante / nombre comercial

USP

mp

293-295 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

formato

neat

cadena SMILES

O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3

InChI

1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)

Clave InChI

CXOFVDLJLONNDW-UHFFFAOYSA-N

Información sobre el gen

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Phenytoin USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Phenytoin Sodium
  • Phenytoin Chewable Tablets
  • Phenytoin Oral Suspension
  • Phenytoin Sodium Injection
  • Extended Phenytoin Sodium Capsules
  • Phenytoin Compounded Topical Gel
  • Fosphenytoin Sodium Injection

Acciones bioquímicas o fisiológicas

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

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1535020

Phenytoin Related Compound B, United States Pharmacopeia (USP) Reference Standard

P1290000

Phenytoin, European Pharmacopoeia (EP) Reference Standard

P1300000

Phenytoin sodium, European Pharmacopoeia (EP) Reference Standard

Y0001167

Phenytoin for system suitability, European Pharmacopoeia (EP) Reference Standard

PHR1492

Phenytoin sodium, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1574

Phenytoin Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1692

Phenytoin Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

BP1238

Phenytoin sodium, British Pharmacopoeia (BP) Reference Standard

PHR2246

1-Methyl-5,5-diphenylimidazolidine-2,4-dione, Pharmaceutical Secondary Standard; Certified Reference Material

PHR9055

Benzil, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2247

5-(4-Methylphenyl)hydantoin

PHR2553

Phenytoin Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Danger

Frases de peligro

H302,H351,H360FD

Clasificaciones de peligro

Acute Tox. 4 Oral - Carc. 2 - Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Deborah Pugin et al.
Critical care (London, England), 18(3), R103-R103 (2014-06-03)
Seizures refractory to third-line therapy are also labeled super-refractory status epilepticus (SRSE). These seizures are extremely difficult to control and associated with poor outcome. We aimed to characterize efficacy and side-effects of continuous infusions of pentobarbital (cIV-PTB) treating SRSE. We
Chunhong Shen et al.
Bone, 64, 246-253 (2014-05-02)
It has been shown that antiepileptic drugs (AEDs) may have a detrimental effect on bone health and translate into an increased risk of bone fracture. We aimed to comprehensively evaluate the association between use of AEDs and fracture risk. We
Syed Nabeel Zafar et al.
BMC neurology, 12, 30-30 (2012-05-31)
Current standard therapy for seizure prophylaxis in Neuro-surgical patients involves the use of Phenytoin (PHY). However, a new drug Levetiracetam (LEV) is emerging as an alternate treatment choice. We aimed to conduct a meta-analysis to compare these two drugs in
Lelia Duley et al.
The Cochrane database of systematic reviews, (10)(10), CD000128-CD000128 (2010-10-12)
Eclampsia, the occurrence of a seizure in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants have been used to control eclamptic fits and to prevent further seizures. The objective of this review
P J Smith et al.
Endocrine reviews, 5(4), 514-524 (1984-01-01)
The studies described above indicate the likelihood of a significant effect of DPH on cellular functions that are regulated by T3 at concentrations of DPH that occur during treatment of patients with Dilantin. Thus, it is possible that sensitive measures
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