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Merck

PHR1139

Supelco

Phenytoin

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

5,5-Diphenylhydantoin, 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin

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About This Item

Fórmula empírica (notación de Hill):
C15H12N2O2
Número de CAS:
Peso molecular:
252.27
Beilstein:
384532
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to Ph. Eur. P1290000
traceable to USP 1535008

familia API

phenytoin

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

mp

293-295 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3

InChI

1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)

Clave InChI

CXOFVDLJLONNDW-UHFFFAOYSA-N

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Descripción general

Phenytoin is a well-known aromatic anticonvulsant which undergoes metabolism in the hepatic microsomal system. It finds its application as the most effective treatment available for seizure disorders. It belongs to the class of phenyl hydantoins compounds. It can hinder the unnecessary activity of the brain during seizures by bringing stability to the sodium channels, causing decreased electrical conductivity among brain cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Phenytoin may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations and combined dosage forms by electrochemical, spectrophotometric, and chromatographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB7779 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Health hazardExclamation mark

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral - Carc. 2 - Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3


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Certificados de análisis (COA)

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Visite la Librería de documentos

Familial occurrence of hypersensitivity to phenytoin
Gennis MA, et al.
The American Journal of Medicine, 91(6), 631-634 (1991)
Phenytoin: pharmacokinetics and bioavailability
Gugler R, et al.
Clinical Pharmacology and Therapeutics, 19(2), 135-142 (1976)
Development and validation of a stability-indicating isocratic reverse phase-liquid chromatography assay for determination of phenytoin in bulk and pharmaceutical formulations
Yong TS and Gan SN
International Journal of Pharmacy and Pharmaceutical Sciences, 38(3), 420-427 (2015)
Cimetidine interaction with phenytoin.
Hetzel DJ, et al.
British Medical Journal, 282(6275), 1512-1512 (1981)
A poly (vinylchloride) membrane electrode for determination of phenytoin in pharmaceutical formulations
Cosofret,VV and Buck RP
Journal of Pharmaceutical and Biomedical Analysis, 4(1), 45-51 (1986)

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