1349706

Isoniazid

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
• Fórmula empírica (notación de Hill): C₆H₇N₃O
• Número de CAS: 54-85-3
• Peso molecular: 137.14
• Beilstein: 119374
• Número MDL: MFCD00006426
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329750199
• NACRES: NA.24

Propiedades

• grado: pharmaceutical primary standard
• familia API: isoniazid
• fabricante / nombre comercial: USP
• mp: 171-173 °C (lit.)
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-8°C
• cadena SMILES: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• Clave InChI: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Descripción

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Isoniazid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Isoniazid Tablets
• Isoniazid Injection
• Isoniazid Oral Solution
• Rifampin and Isoniazid Capsules
• Rifampin, Isoniazid, and Pyrazinamide Tablets
• Rifampin, Isoniazid, Pyrazinamide, and Ethambutol Hydrochloride Tablets

Acciones bioquímicas o fisiológicas

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H315
• Consejos de prudencia: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Clasificaciones de peligro: Acute Tox. 4 Oral - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3