E4630

Ethambutol dihydrochloride

antimycobacterial

• Sinónimos: Ethambutol, Ethambutol HCL, 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride, Emb
• Fórmula empírica (notación de Hill): C₁₀H₂₄N₂O₂ · 2HCl
• Número de CAS: 1070-11-7
• Peso molecular: 277.23
• Número CE: 213-970-7
• Número MDL: MFCD21364080
• Código UNSPSC: 51281511
• ID de la sustancia en PubChem: 24894566
• NACRES: NA.85

Propiedades

• Nivel de calidad: 200
• Formulario: powder
• actividad óptica: [α]25/D 6.0 to 6.7°, c = 10 in water
• color: white
• solubilidad: H₂O: 50 mg/mL
• espectro de actividad antibiótica: mycobacteria
• Modo de acción: cell wall synthesis | interferes
• cadena SMILES: CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl
• InChI: 1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
• Clave InChI: AUAHHJJRFHRVPV-BZDVOYDHSA-N

Descripción

Aplicación

Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance.

Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.

Acciones bioquímicas o fisiológicas

Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.

Ethambutol specifically inhibits arabinosyltransferases in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges